منابع مشابه
Th2 cells: help for helminths
L ndmark studies by Mosmann and Coffman in the midto-late 1980s established the division of a number of murine CD4 § T cells clones into distinct subsets, designated Thl and Th2 cells, that mediate their effector functions through the elaboration of distinct groups of cytokines (1). Thl cells uniquely generate IFN-% lymphotoxin, and Ib2 after stimulation, whereas Th2 cells uniquely generate I1-...
متن کاملPriming Dendritic Cells for Th2 Polarization: Lessons Learned from Helminths and Implications for Metabolic Disorders
Nearly one quarter of the world's population is infected with helminth parasites. A common feature of helminth infections is the manifestation of a type 2 immune response, characterized by T helper 2 (Th2) cells that mediate anti-helminth immunity. In addition, recent literature describes a close association between type 2 immune responses and wound repair, suggesting that a Th2 response may co...
متن کاملTh1 and Th2 cells help CD8 T-cell responses.
Help from CD4 T cells is often important for the establishment of primary and memory CD8 T-cell responses. However, it has yet to be determined whether T helper polarization affects the delivery of help and/or whether responding CD8 T cells helped by Th1 or Th2 cells express distinct effector properties. To address these issues, we compared CD8 T-cell responses in the context of Th1 or Th2 help...
متن کاملInterleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths
Immunity to intestinal helminth infections requires the rapid activation of T helper 2 cells (Th2 cells). However, simultaneous expansion of CD4+Foxp3+ regulatory T cells (T reg cells) impedes protective responses, resulting in chronic infections. The ratio between T reg and effector T cells can therefore determine the outcome of infection. The redifferentiation of T reg cells into Th cells has...
متن کاملAlarming dendritic cells for Th2 induction
There is an ever-increasing understanding of the mechanisms by which pathogens such as bacteria, viruses, and protozoa activate dendritic cells (DCs) to drive T helper type 1 (Th1) responses, but we know much less about how these cells elicit Th2 responses. This gap in our knowledge puts us at a distinct disadvantage in designing therapeutics for certain immune-mediated diseases. However, progr...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1994
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.179.5.1405